Massimo Santoro Tubito was born in Altamura on December 1660. Massimo Santoro Tubito or Latin: Maximus Xanthorus Tubitus (December 1660 - ...) was an Italian priest and writer. Massimo Santoro Tubito or Latin: Maximus Xanthorus Tubitus (December 1660 - ...) was an Italian priest and writer. Here, we identified a gene with important antioxidant features by analyzing a null allele of zebrafish ubiad1, called barolo (bar). View Massimo Santoro’s profile on LinkedIn, the world's largest professional community. Endothelial cell regression is obser... microRNAs (miRNAs) have a pivotal role during the formation and function of the cardiovascular system. Join Facebook to connect with Massimo Santoro and others you may know. Supplementary Figures 1 - 14 and Supplementary Tables 1 - 3. Surrounded by the Passo delle Erbe, the Plose and the alp of Luson, I was able to make valuable experiences that continue to influence me until today. The liver kinase B1 (LKB1) gene is a tumor suppressor associated with the hereditary Peutz-Jeghers syndrome and frequently mutated in non-small cell lung cancer and in cervical cancer. massimo-santoro.com Massimo has 6 jobs listed on their profile. The MSP receptor regulates ±6²4 and ±3²1 integrins via 14-3-3 proteins in keratinocyte re-epithelization. This review therefore first describes the role and regulation of mural cells during vascular formation, with a focus on embryoni... Congenital or neonatal cardiomyopathies are commonly associated with a poor prognosis and have multiple etiologies. Article plus Supplemental Information, An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates, Blood flow controls bone vascular function and osteogenesis, *PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis, Contribution of sclerotome to the hematopoietic stem cell niche, “Decoding” Angiogenesis: New Facets Controlling Endothelial Cell Behavior, ROS homeostasis and metabolism: A dangerous liason in cancer cells, Rapid high performance liquid chromatography-high resolution mass spectrometry methodology for multiple prenol lipids analysis in zebrafish embryos, Vascular Mural Cells Promote Noradrenergic Differentiation of Embryonic Sympathetic Neurons, ROS signaling and redox biology in endothelial cells, The Dlx5 and Foxg1 transcription factors, linked via miRNA-9 and -200, are required for the development of the olfactory and GnRH system, Heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation, Zebrafish as a model to explore cell metabolism, Analysis of Oxidative Stress in Zebrafish Embryos, Antiangiogenic Cancer Drug Using the Zebrafish Model, ZebraBeat : A flexible platform for the analysis of the cardiac rate in zebrafish embryos, An α-Smooth Muscle Actin (acta2/αsma) Zebrafish Transgenic Line Marking Vascular Mural Cells and Visceral Smooth Muscle Cells, Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis, Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome, 13C-isotope-based protocol for prenyl lipid metabolic analysis in zebrafish embryos, Tumor Angiogenesis: Fishing for Screening Models, DISTINCT ROLES OF FLVCR1 ISOFORMS IN PRIMITIVE AND DEFINITIVE ERYTHROPOIESIS, ENDOTHELIAL DELETION OF FLVCR1A ALTERS VASCULAR INTEGRITY. D, deleteri... Pedigree of the family. 1 “Neuroendocrine aspects of cutaneous melanoma: focus on somatostatin receptors (SSTRs) expression and role of the pan-SSTR-agonist Pasireotide on cell proliferation” 2 We have previously sh... Cutaneous wound healing is a highly coordinated physiological process that rapidly and efficiently restores skin integrity. The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved! The covalent attachment of ubiquitin to target proteins influences various cellular processes, including DNA repair, NF-kappaB signalling and cell survival. The toponym Altilia lacks historical evidence, and most scholars - such as Ottavio Serena - tend to reject it. DII4 Inhibition Alters Blood Flow, in Support of Data Shown in Figure 4 Feline Leukemia Virus subgroup C Receptor 1 (Flvcr1) encodes two heme exporters: Flvcr1a, that localizes to the plasma membrane, and Flvcr1b, that localizes to mitochondria. Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis, Movie S3. In two siblings, a male and female, we identified an undescribed type of lethal congenital restrictive cardiomyopathy affecting the right ventricle. Besides glycolysis and fatty acid oxidation, endothelial cells rely on specific amino acids to proliferate, migrate, and survive. He was member of the so-called Accademia degli Spensierati. Since its introduction, the zebrafish has provided an important reference system to model and study cardiovascular development as well as lymphangiogenesis in vertebrates. Whereas such oxidative stress conditions would be harmful to normal cells, they facilitate tumor growth in multiple ways by causing DNA damage and genomic instability, and ultimately, by reprogramming cancer cell metabolism. Unraveling how E3 ligases are regulated is important because miscontrolled ubiquitylation can lead to disease. Dettaglio. Nome completo SANTORO, MASSIMO Afferenza Dipartimento di Biologia (DiBio) Pubblicazioni. from different tissues. In cardiovascular tissues microRNAs play a role by modulating essential genes involved in heart and blood vessel development and homeostasis. bar mutants show specific... Wild-type siblings embryos were analyzed for endothelial cell development at the level of the trunk vasculature. All rights reserved. Previous studies showed that the LKB1/AMPK axis is involved in regulation of cell death and survival under metabolic stress. His father was Angelo Tubito, while his mother was Angela Perillo. II-2 and II-3 were diagnosed with restrictive cardiomyopathy, patients demised at the age of 6 and 3 months respectively. In vivo models of vascular mural... During embryonic development, immature neurons in the olfactory epithelium (OE) extend axons through the nasal mesenchyme, to contact projection neurons in the olfactory bulb. Massimo Santoro is a member of Vimeo, the home for high quality videos and the people who love them. Massimo Santoro is an actor, known for Sono cavoli amari (2011) and My Brilliant Friend (2018). The books are also known because he refers to himself as Latin: Altiliensis, seu Altamuranus which means "Altiliens or Altamuran", denoting that he was from the Apulian city of Altamura. Length of recording is 7 hours (5 frames/sec). (TIF). This is a crucial biological event in all vertebrates. The recent availability of novel technologies and organisms to model cell metabolism in vivo is expanding current knowledge of cell metabolism. HsKIF20A, human KIF20A gene and Drkif20a, zebrafish kif20a gene are shown in alignment. Visualizza il profilo di Massimo Santoro su LinkedIn, la più grande comunità professionale al mondo. Knock-down of Cathepsin D in zebrafish fertilized eggs determines congenital myopathy. ST-GFP is clearly localized at the TGN cisternae and in peripheral post-Golgi vesicles that very frequently target cherry vinculin enriched adhesion sites. In the past years, evidence has emerged that hallmarks of human metabolic disorders can be recapitulated in zebrafish using genetic, pharmacological or dietary interventions. (TIF), Histology with H&E staining of the myocardium in the index patient. SANTORO, MASSIMO. Due to our privacy policy, only current members can send messages to people on ResearchGate. The laboratory of Massimo Santoro at University of Padua strives to understand blood vessels biology and cell metabolism in pathological angiogenesis and cancer progression. Supplemental Experimental Methods and Figures S1–S13, Document S2. Here, we identified microRNAs that were enriched in endothelial cells derived from mous... Diacylglycerol kinases (Dgk) phosphorylate diacylglycerol (DG) to phosphatidic acid (PA), thus turning off and on, respectively, DG-mediated and PA-mediated signaling pathways. Endothelial cell regression is observed throughout... barolo (bar) mutant embryos were analyzed for endothelial cell disintegration at the level of the trunk vasculature. Loop is the open research network that increases the discoverability and impact of researchers and their work. Job Title Group Leader, Laboratory of Angiogenesis and Redox Metabolism Address Department of Biology, University of Padua, Italy Biography The contact between the two buds gradually disappears and a loop structure is established. The lysosomal aspartic protease Cathepsin D (CD) is ubiquitously expressed in eukaryotic organisms. It is a domain having com extension. I am Massimo Santoro, I am from Florence. remain elusive. Rete di Collaborazioni Statistiche Email Alert RSS Feed. ST-GFP+ PGCs clearly target PPFIA1 enriched areas around vinculin containing adhesion sites. The red arrows indicate the cardiac region where cardiac oedema is pronounced in the morphants and absent in controls. To identify the cause, we perf... Amino acid sequence alignment of human and zebrafish KIF20A genes. CD may also act at physi... E3 ligases mediate the covalent attachment of ubiquitin to target proteins thereby enabling ubiquitin-dependent signaling. To pursue these molecular and pharmacological approaches, researchers need to develop... Cathepsin D (CD) is an ubiquitous lysosomal hydrolase involved in a variety of pathophysiological functions, including protein turnover, activation of pro-hormones, cell death and embryo development. (TIF). Recent and new tools to inve... During neuronal development and maturation, microRNAs (miRs) play diverse functions ranging from early patterning, proliferation and commitment to differentiation, survival, homeostasis, activity and plasticity of more mature and adult neurons. The function of hemodynamic forces in controlling vMC recruitment is unclear. My name is Massimo Santoro, I am 25 years old and I live in Bressanone (Italy). Massimo Santoro नाम के लोगों की प्रोफ़ाइल देखें. The analysis of lipid molecules in living organism is an important step in deciphering metabolic pathways. Anastomosis of two buds in the vascular front of Flk1-GFP (green, blood vessels) metatarsal bone. View the profiles of people named Massimo Santoro. Live time-lapse total internal reflection fluorescence (TIRF) microscopy of an EC that was co-transfected with the TGN marker ST-GFP (green), PPFIA1-Cherry (red) and adhesion site protein vinculin-CFP (blue). Ron can acquire oncogenic potential by single point mutations in the kinase domain, and dysregulated See the complete profile on LinkedIn and discover Massimo’s connections and jobs at similar companies. CD activity is essential to accomplish the acid-dependent extensive or partial proteolysis of protein substrates within endosomal and lysosomal compartments therein delivered via endocytosis, phagocytosis or autophagocytosis. Recent studies have identified a specific role for microRNAs as key regulators of vascular function and dysfunction. My main passion is coffee but I also like personal development and challenges. These aspects are particularly relevant in cardiovascular tissues wherein alterations of the redox balance are associated with stroke, aging, and pharmacological inter... Vascular mural cells (vMCs) are essential components of the vertebrate vascular system, controlling blood vessel maturation and homeostasis. A better understanding of the mechanisms that regulates such process is mandatory to intervene in pathophysiological conditions. Massimo has 4 jobs listed on their profile. Zebrafish have been increasingly used for transgenesis studies mainly due to easy egg accessibility and manipulation together with relatively short generation time. Formation and maturation of a functional vascular network is a process called angiogenesis. Santoro, G. Gaudino and P.C. Massimo Santoro, in Italy. z Stack time-lapse movies of Tg(kdrl:GFP)s843barolot31131 (bar) mutants between 48 and 60 hpf show vascular integrity disintegration in the trunk vasculature (arrows) progressively through 60 hpf. We hypothesized a novel autosomal recessive condition. Here we show that the long bone vasculature generates a peculiar flow pattern, which is important for proper angiogenesis. (TIF), Zebrafish kif20a knockdown studies. View Massimo Santoro’s profile on LinkedIn, the world’s largest professional community. Live time-lapse total internal reflection fluorescence (TIRF) microscopy of an EC that was co-transfected with the TGN marker ST-GFP (green) and adhesion site protein Cherry-vinculin (red). Wild-type siblings embryos were analyzed for endothelial cell development at the level of the trunk vasculature from 32 to 48 hpf. Live time-lapse phase contrast microscopy of MO-ppfia1 injected Tg(kdrl:EGFP) zebrafish embryo at 48 hpf. (2019) have identified FSP1 as a novel CoQ10 plasma membrane oxidoreductase, protecting cells from glutathione-independen... Hematopoietic stem cells (HSCs) are a self-renewing population that sustains production of blood lineages throughout life. Time-lapse confocal fluorescence microscopy reveals normal heart beating in a representative 48 hpf MO-ppfia1 injected Tg(kdrl:EGFP) zebrafish embryo. Time-Lapse Movies Showing Normal Endothelial Development in bar Mutant Embryos between 48 and 60 hpf, Related to Figure 1, Movie S1. Massimo Mattia Santoro obtained is Master Diploma from University of Turin, Italy and his PhD in Molecular and Cellular Biology from the Open University, London, UK. The process of de novo vessel formation, called angiogenesis, is essential for tumor progression and metastasis. [5][6], The birth date and country are given in the paragraph in latin, de-antichristo1712, intestazione (pagina iniziale), "Elogj Accademici della Società Degli Spensierati di Rossano ... Publicati da Gaetano Tremigliozzi Consiglier-Promotoriale, Colle Memorie Storiche della Società Stessa aggiunte dal Medesimo", "Archivio storico per le province Napoletane", https://en.wikipedia.org/w/index.php?title=Massimo_Santoro_Tubito&oldid=998050997, Creative Commons Attribution-ShareAlike License, This page was last edited on 3 January 2021, at 15:46. Massimo Santoro और अपने अन्य परिचितों से जुड़ने के लिए Facebook में शामिल करें. (2019) and Doll et al. Massimo Santoro, Actor: Sono cavoli amari. The three candidate genes with variants after stringent filtering; for each gene the gene name, transcript number, cDNA position (c.), protein position (p.) and exon number; three in silico prediction programs (SIFT, Polyphen and MutationTaster), 1000 Genomes (%), ExAC Browser Database (number of alleles) and local exomes (%) are shown. Right ventricle myocardium showing (A) evident subendocardial fibrosis with disrupted myocardial architecture, (B) persistent right ventricular sinusoids and increased fibrosis and (C) myocytolysis. Gwangju Institute of Science and Technology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Cancer Institute (USA), till 2008, Università del Piemonte Orientale, Amedeo Avogadro, Novara, Division of Pediatrics & Hemoglobinopathies Centre, Institute of Genetic and Biomedical Research IRGB, Latrophilin 2 controls vascular morphogenesis and function by inhibiting endothelial cell adhesion and YAP/TAZ mechanosignaling. View the profiles of people named Massimo Santora. Blood flow pattern in diaphysis. Indeed, the zebrafish heart is easily accessible for optical analyses... Mural cells of the vascular system include vascular smooth muscle cells (SMCs) and pericytes whose role is to stabilize and/or provide contractility to blood vessels. The process of de novo vessel formation, called angiogenesis, is essential for tumor progression and spreading. I have been a Barista for several years—I moved to France 6 years ago, where I refined and developed my Barista skills. The role of endothelial metabolism represents a crucial element governing the formation and the differentiation of blood vessels, termed angiogenesis. He's best known for his books Divinum Theatrum (1702) and De Antichristo (1712), both of them written in Latin. Time-Lapse Movies Showing Normal Endothelial Development in bar Mutant Embryos between 32 and 48 hpf, Related to Figure 1, Movie S2. Altiliensis refers to the legends about the founding of the city of Altamura, whose ancient name is believed to have been Altilia. 2:57. Reepithelization is a crucial step during wound healing, which involves migration and proliferation of keratinocytes to cover the denuded dermal surface. Length of recording is 29 mins (5 frames/sec). Axon navigation is accompanied by migration of the GnRH+ neurons, which enter the anterior forebrain and home in the septo-hypothalamic area. The transgenic zebrafish e... Detecting and measuring the dynamic redox events that occur in vivo is a prerequisite for understanding the impact of oxidants and redox events in normal and pathological conditions. Marchisio. In this context, the zebrafish (Danio rerio) is emerging as a valuable model system to learn about the metabolic routes critical for... High levels of reactive oxygen species (ROS) may cause a change of cellular redox state towards oxidative stress condition. Sorry, you need to be a researcher to join ResearchGate. Using transgenic lines marking develop... Movie S1. Length of recording is 22 mins (5 frames/sec). Recently, both Bersuker et al. La figlia di Rita dalla Chiesa, Giulia Cirese in lutto: è morto il marito Massimo Santoro - Duration: 2:57. showbiz news 146,860 views. Guarda il profilo completo su LinkedIn e scopri i collegamenti di Massimo e le offerte di lavoro presso aziende simili. The identification and targeting of the molecular pathways involved in this process are becoming critical issues for anti-angiogenic cancer therapies. Massimo Santoro . CD-mediated proteolysis plays a pivotal role in tissue and organ homeostases. Intravital imaging movie of extending bud in the vascular front of 10-day Flk1-GFP (green, blood vessels) metatarsal. Postganglionic sympathetic neurons (SNs) develop in close proximity to the dorsal aorta (DA) and innervate visceral smooth muscle targets. Wejdź i znajdź to, czego szukasz! © 2008-2021 ResearchGate GmbH. In dll4 KD, only in functional SeA Notch is active. The genetic and molecular mechanisms regulating these processes in vivo are still largely unknown. The zebrafish transgen... Angiogenesis, the formation of new blood vessels, is a unique and crucial biological process occurring during both development and adulthood. The subjects covered are history and religion. Length of recording is 1.5 hours (5 frames/sec). Intestinal smooth muscle cells (iSMCs) are a critical component of the adult gastrointestinal (GI) tract and support intestinal differentiation, peristalsis, and epithelial homeostasis during development. The parents and older sibling have a normal phenotype. Here, we use the zebrafish embryo to ask whether the DA is required for SN development. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Dynamic modulation of endothelial cell (EC) adhesion to extracellular matrix (ECM) in response to mechanostimuli is essential for blood vessel patterning and functioning. The overall similarity between zebrafish and human in response to cardiotoxic drugs was demonstrated, for example, in drug-induced cardiac arrhythmia.

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