Massimo has 4 jobs listed on their profile. The subjects covered are history and religion. In this article we used transgenic zebrafish lines that express compartment-specific isoforms of the roGFP2-Orp1 and Grx1-roGFP2 biosensors, described in [1], to test the contribute of the pentose phosphate pathway and of the glutathione biosynthesis in the antioxidant capacity of myocardial and endothelial cells in vivo. Supplemental Experimental Methods and Figures S1–S13, Document S2. Precise morphogenetic and cellular mechanisms act in endothelial cells (ECs) to drive angiogenesis during growth and throughout adulthood. The zebrafish transgen... Angiogenesis, the formation of new blood vessels, is a unique and crucial biological process occurring during both development and adulthood. Previous studies showed that the LKB1/AMPK axis is involved in regulation of cell death and survival under metabolic stress. My main passion is coffee but I also like personal development and challenges. Here we describe a protocol for fast and reliable (13)C-isotope-based in vivo metabolic profiling. Targeting of molecular pathways involved in such tumor angiogenetic processes by using specific drugs or inhibitors is important for developing new anticancer therapies. In this review we present an overview of the currentlyknowendo... MicroRNAs are small non-coding RNAs endogenously expressed by all tissues during development and adulthood. More than 300 miRNAshave been currently found within the mammalian genome, however only few specific miRNAs, named endomiRNAs, showed conseved endothelial cell expression and function. Massimo Santoro Tubito was born in Altamura on December 1660. (2019) have identified FSP1 as a novel CoQ10 plasma membrane oxidoreductase, protecting cells from glutathione-independen... Hematopoietic stem cells (HSCs) are a self-renewing population that sustains production of blood lineages throughout life. [2] According to other historians, such as Tommaso Berloco (1985), there isn't enough evidence either to dismiss the toponym or to prove it.[3]. Article plus Supplemental Information, An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates, Blood flow controls bone vascular function and osteogenesis, *PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis, Contribution of sclerotome to the hematopoietic stem cell niche, “Decoding” Angiogenesis: New Facets Controlling Endothelial Cell Behavior, ROS homeostasis and metabolism: A dangerous liason in cancer cells, Rapid high performance liquid chromatography-high resolution mass spectrometry methodology for multiple prenol lipids analysis in zebrafish embryos, Vascular Mural Cells Promote Noradrenergic Differentiation of Embryonic Sympathetic Neurons, ROS signaling and redox biology in endothelial cells, The Dlx5 and Foxg1 transcription factors, linked via miRNA-9 and -200, are required for the development of the olfactory and GnRH system, Heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation, Zebrafish as a model to explore cell metabolism, Analysis of Oxidative Stress in Zebrafish Embryos, Antiangiogenic Cancer Drug Using the Zebrafish Model, ZebraBeat : A flexible platform for the analysis of the cardiac rate in zebrafish embryos, An α-Smooth Muscle Actin (acta2/αsma) Zebrafish Transgenic Line Marking Vascular Mural Cells and Visceral Smooth Muscle Cells, Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis, Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome, 13C-isotope-based protocol for prenyl lipid metabolic analysis in zebrafish embryos, Tumor Angiogenesis: Fishing for Screening Models, DISTINCT ROLES OF FLVCR1 ISOFORMS IN PRIMITIVE AND DEFINITIVE ERYTHROPOIESIS, ENDOTHELIAL DELETION OF FLVCR1A ALTERS VASCULAR INTEGRITY. (2019) and Doll et al. Tutti (70) Tutti (70) Contributo in rivista (59) Contributo in volume (6) Brevetto (1) Esportazione . See the complete profile on LinkedIn and discover Massimo’s connections and jobs at similar companies. Black highlighting shows identical residues with the red star indicating the conserved R182 residue in human and zebrafish. Zebrafish have been increasingly used for transgenesis studies mainly due to easy egg accessibility and manipulation together with relatively short generation time. Here, we identified microRNAs that were enriched in endothelial cells derived from mous... Diacylglycerol kinases (Dgk) phosphorylate diacylglycerol (DG) to phosphatidic acid (PA), thus turning off and on, respectively, DG-mediated and PA-mediated signaling pathways. Santoro, G. Gaudino and P.C. The lysosomal aspartic protease Cathepsin D (CD) is ubiquitously expressed in eukaryotic organisms. Spinning disk microscopy shows blood circulation (red) in ctrl (A) and dll4 KD (B) in Tg(tp1:egfp)um14Tg(gata1:DsRed)sd2 at 4 dpf. In addition, imbalance in blood vessel growth contributes to the pathogenesis of numerous disorders. The overall similarity between zebrafish and human in response to cardiotoxic drugs was demonstrated, for example, in drug-induced cardiac arrhythmia. CONTRIBUTION OF SCLEROTOME TO THE EMBRYONIC HEMATOPOIETIC STEM CELL NICHE AND VASCULAR SMOOTH MUSCLE, Advantages and Challenges of Cardiovascular and Lymphatic Studies in Zebrafish Research, Nano-Sampling and Reporter Tools to Study Metabolic Regulation in Zebrafish, Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells, Before the Pump: The Importance of Cilia in Cranial Development, Photobiomodulation at Multiple Wavelengths Differentially Modulates Oxidative Stress In Vitro and In Vivo, Role of amino acid metabolism in angiogenesis, LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and γ-irradiation, Contribution of Sclerotome to the Hematopoietic Stem Cell Niche and Vascular Smooth Muscle, New models to study vascular mural cell embryonic origin: Implications in vascular diseases, Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings, RENDOX-REDOX SIGNALING AND METABOLISM IN HEALTH AND DISEASED ANGIOGENESIS, Fashioning blood vessels by ROS signalling and metabolism, Data on Metabolic-dependent antioxidant response in the cardiovascular tissues of living zebrafish under stress conditions, Real-time quantification of subcellular H2O2 and glutathione redox potential in living cardiovascular tissues, Cilia Control Vascular Mural Cell Recruitment in Vertebrates, Document S1. The process of de novo vessel formation, called angiogenesis, is essential for tumor progression and metastasis. Giulio santoro na Allegro.pl - Zróżnicowany zbiór ofert, najlepsze ceny i promocje. Bright-field images of zebrafish control and kif20a morphants at 4 dpf. Massimo Santoro is an actor, known for Sono cavoli amari (2011) and My Brilliant Friend (2018). Marchisio. Massimo Santoro, Actor: Sono cavoli amari. Massimo Santoro नाम के लोगों की प्रोफ़ाइल देखें. Formation of a functional vasculature during mammalian development is essential for embryonic survival. See also Other Works | Publicity Listings | Official Sites That’s why I’m competing, to show that I … z Stack time-lapse movies of Tg(kdrl:GFP)s843barolot31131 (bar) mutants between 32 and 48 show vascular integrity disintegration in the trunk vasculature (arrows) starting at 32 hpf. Precise regulation of the formation, maintenance, and remodeling of the vasculature is required for normal development, tissue response to injury, and tumor progression. One of the earliest markers of mural cell development in vertebrates is α smooth muscle actin (acta2; αsma), which is expressed by pericytes and SMCs. Time-Lapse Movies Showing Normal Endothelial Development in bar Mutant Embryos between 48 and 60 hpf, Related to Figure 1, Movie S1. Discrete molecular mechanisms have been associated with vMC development and differentiation. We hypothesized a novel autosomal recessive condition. A better understanding of the mechanisms that regulates such process is mandatory to intervene in pathophysiological conditions. Massimo Santoro Executive Chef di cucina, consulenze di gestione e di avviamento In cardiovascular tissues microRNAs play a role by modulating essential genes involved in heart and blood vessel development and homeostasis. Nome completo SANTORO, MASSIMO Afferenza Dipartimento di Biologia (DiBio) Pubblicazioni. In the past years, evidence has emerged that hallmarks of human metabolic disorders can be recapitulated in zebrafish using genetic, pharmacological or dietary interventions. Surrounded by the Passo delle Erbe, the Plose and the alp of Luson, I was able to make valuable experiences that continue to influence me until today. Recently, both Bersuker et al. Blood flow recorded in the metaphysis of 10-day old Flk1-GFP (green, blood vessels) mouse after intra-venous injection of dextran (red). Recent and new tools to inve... During neuronal development and maturation, microRNAs (miRs) play diverse functions ranging from early patterning, proliferation and commitment to differentiation, survival, homeostasis, activity and plasticity of more mature and adult neurons. Massimo Santoro Donatella Tramontano Giancarlo Troncone Giancarlo Vecchio Giuseppe Viglietto Mario Vitale. ?B as well as cell survival and oncogenesis, miR-126 Regulates Angiogenic Signaling and Vascular Integrity, Diacylglycerol Kinase- Mediates Hepatocyte Growth Factor-induced Epithelial Cell Scatter by Regulating Rac Activation and Membrane Ruffling, Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis, A Transgene-Assisted Genetic Screen Identifies Essential Regulators of Vascular Development in Vertebrate Embryos, Geldanamycins Trigger a Novel Ron Degradative Pathway, Hampering Oncogenic Signaling, Cellular and molecular facets of keratinocyte reepithelization during wound healing, Dipartimento di Scienze Cliniche e Biologiche, Department of Biochemistry and Biophysics, DIMEAS - Department of Mechanical and Aerospace, Immunology and Diagnostic Molecular Oncology, Department of Surgery, Oncology and Gastroenterology DISCOG, Dipartimento di Oncologia Sperimentale e Medicina Molecolare. Massimo M has 4 jobs listed on their profile. 2:57. While blood vessels play important roles in bone homeostasis and repair, fundamental aspects of vascular function in the skeletal system remain poorly understood. Massimo Santoro is a member of Vimeo, the home for high quality videos and the people who love them. This review therefore first describes the role and regulation of mural cells during vascular formation, with a focus on embryoni... Congenital or neonatal cardiomyopathies are commonly associated with a poor prognosis and have multiple etiologies. Massimo Santoro is on Facebook. [5][6], The birth date and country are given in the paragraph in latin, de-antichristo1712, intestazione (pagina iniziale), "Elogj Accademici della Società Degli Spensierati di Rossano ... Publicati da Gaetano Tremigliozzi Consiglier-Promotoriale, Colle Memorie Storiche della Società Stessa aggiunte dal Medesimo", "Archivio storico per le province Napoletane", https://en.wikipedia.org/w/index.php?title=Massimo_Santoro_Tubito&oldid=998050997, Creative Commons Attribution-ShareAlike License, This page was last edited on 3 January 2021, at 15:46. [4] Both the death date and the death place are unknown. Movie showing the blood flow pattern in the Flk1-GFP (green, blood vessels) diaphysis after intravenous injection of dextran (red). Massimo Santoro और अपने अन्य परिचितों से जुड़ने के लिए Facebook में शामिल करें. 0 Followers, 0 Following, 0 Posts - See Instagram photos and videos from massimo santoro (@massimo_santoro) (TIF), Represents the LOD score in function of the chromosomal position in centimorgan (cM). 1 “Neuroendocrine aspects of cutaneous melanoma: focus on somatostatin receptors (SSTRs) expression and role of the pan-SSTR-agonist Pasireotide on cell proliferation” 2 The emergence of a bulge structure from the loop is evident in the movie. Altiliensis refers to the legends about the founding of the city of Altamura, whose ancient name is believed to have been Altilia. Basolateral polymerization of cellular fibronectin (FN) into a meshwork drives endothelial Time-Lapse Movies Show that Endothelial Disintegration in bar Mutant Embryos between 48 and 60 hpf, Related to Figure 1, MiRNAs in endothelial cell signaling: The endomiRNAs, The admiR-able advances in cardiovascular biology through the zebrafish model system, MiRNAs controlling developmental angiogenesis and vascular maturation in zebrafish, IMAGE-BASED AUTOMATIC METHOD TO NOT INVASIVELY MONITOR THE HEART RHYTHM OF ZEBRAFISH EMBRYOS, "Fishing" for endothelial microRNA functions and dysfunction, Knock-Down of Cathepsin D Affects the Retinal Pigment Epithelium, Impairs Swim-Bladder Ontogenesis and Causes Premature Death in Zebrafish, CARD-Mediated Autoinhibition of cIAP1's E3 Ligase Activity Suppresses Cell Proliferation and Migration, Phylogeny informs ontogeny: A proposed common theme in the arterial pole of the vertebrate heart, A NON-INVASIVE TOOL TO ASSESS HEART RHYTHM IN ZEBRAFISH EMBRYOS, Characterization of Vascular Mural Cells During Zebrafish Development, IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-? integrin-mediated extracellular FN endocytosis and exocytosis of newly synthesized FN Formation and maturation of a functional vascular network is a process called angiogenesis. Dettaglio. It is a domain having com extension. Although confirmed as the primary lipophilic antioxidant molecule endogenously produced by cells, the non-mitochondrial pool of CoQ10's functional role is still well debated. The subjects covered are history and religion. Find out all projects and works of Massimo Santoro on Archilovers. The covalent attachment of ubiquitin to target proteins influences various cellular processes, including DNA repair, NF-kappaB signalling and cell survival. The red arrows indicate the cardiac region where cardiac oedema is pronounced in the morphants and absent in controls. This situation causes oxidation of molecules (lipid, DNA, protein) and leads to cell death. Job Title Group Leader, Laboratory of Angiogenesis and Redox Metabolism Address Department of Biology, University of Padua, Italy Biography Endothelial cell regression is obser... microRNAs (miRNAs) have a pivotal role during the formation and function of the cardiovascular system. (TIF). Massimo Santoro is an actor, known for Sono cavoli amari (2011) and My Brilliant Friend (2018). Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis, Movie S3. View Massimo Santoro’s profile on LinkedIn, the world's largest professional community. Intravital imaging movie of extending bud in the vascular front of 10-day Flk1-GFP (green, blood vessels) metatarsal. Cell metabolism plays a key role in many essential biological processes. CD activity is essential to accomplish the acid-dependent extensive or partial proteolysis of protein substrates within endosomal and lysosomal compartments therein delivered via endocytosis, phagocytosis or autophagocytosis. Here, we investigated the role of the two Flvcr1 isoforms during erythropoiesis. ST-GFP is clearly localized at the TGN cisternae and in peripheral post-Golgi vesicles that very frequently target cherry vinculin enriched adhesion sites. Zebrafish (Danio rerio) has emerged as one of the most useful model organisms for cardiac research. Details ; 1 posts ; Male ; … To identify the cause, we perf... Amino acid sequence alignment of human and zebrafish KIF20A genes. Visualizza il profilo di Massimo Santoro su LinkedIn, la più grande comunità professionale al mondo. The process of de novo vessel formation, called angiogenesis, is essential for tumor progression and spreading. My name is Massimo Santoro, I am 25 years old and I live in Bressanone (Italy). Wild-type siblings embryos were analyzed for endothelial cell development at the level of the trunk vasculature from 32 to 48 hpf. He's best known for his books Divinum Theatrum (1702) and De Antichristo (1712), both of them written in Latin. View Massimo M Santoro’s profile on LinkedIn, the world's largest professional community. Postganglionic sympathetic neurons (SNs) develop in close proximity to the dorsal aorta (DA) and innervate visceral smooth muscle targets. The genetic and molecular mechanisms regulating these processes in vivo are still largely unknown. Here we show that the glycolytic enzyme pyruvate kinase M2 (PKM2) limits glucose oxidation, and maintains the growth and epigenetic state of ECs... Photobiomodulation (PBM) is emerging as an effective strategy for the management of multiple inflammatory conditions, including oral mucositis (OM) in cancer patients who receive chemotherapy or radiotherapy. Massimo Santoro Changed his profile picture . I have been a Barista for several years—I moved to France 6 years ago, where I refined and developed my Barista skills. In particular, we describe which molecules are involved in redox signaling and how they influence the relationship between ECs and other vascular component with regard to angiogenesis. To pursue these molecular and pharmacological approaches, researchers need to develop... Cathepsin D (CD) is an ubiquitous lysosomal hydrolase involved in a variety of pathophysiological functions, including protein turnover, activation of pro-hormones, cell death and embryo development. View the profiles of people named Massimo Santoro. Formation of a loop structure from the buds. Massimo Mattia Santoro obtained is Master Diploma from University of Turin, Italy and his PhD in Molecular and Cellular Biology from the Open University, London, UK. Massimo Santoro Tubito or Latin: Maximus Xanthorus Tubitus (December 1660 - ...) was an Italian priest and writer. Indeed, the zebrafish heart is easily accessible for optical analyses... Mural cells of the vascular system include vascular smooth muscle cells (SMCs) and pericytes whose role is to stabilize and/or provide contractility to blood vessels. The MSP receptor regulates ±6²4 and ±3²1 integrins via 14-3-3 proteins in keratinocyte re-epithelization. This website is estimated worth of $ 8.95 and have a daily income of around $ 0.15. Dynamic modulation of endothelial cell (EC) adhesion to extracellular matrix (ECM) in response to mechanostimuli is essential for blood vessel patterning and functioning. Here, we identified a gene with important antioxidant features by analyzing a null allele of zebrafish ubiad1, called barolo (bar). Developmental Cell, 5: 257-271, 2003. Since its introduction, the zebrafish has provided an important reference system to model and study cardiovascular development as well as lymphangiogenesis in vertebrates. Gwangju Institute of Science and Technology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Cancer Institute (USA), till 2008, Università del Piemonte Orientale, Amedeo Avogadro, Novara, Division of Pediatrics & Hemoglobinopathies Centre, Institute of Genetic and Biomedical Research IRGB, Latrophilin 2 controls vascular morphogenesis and function by inhibiting endothelial cell adhesion and YAP/TAZ mechanosignaling. Join Facebook to connect with Massimo Santora and others you may know. However, mechanisms coordinating a5b1 Recent studies have identified a specific role for microRNAs as key regulators of vascular function and dysfunction. In this context, the zebrafish (Danio rerio) is emerging as a valuable model system to learn about the metabolic routes critical for... High levels of reactive oxygen species (ROS) may cause a change of cellular redox state towards oxidative stress condition. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. In dll4 KD, only in functional SeA Notch is active. Wejdź i znajdź to, czego szukasz! (TIF). Vertebrate HSCs are first specified in the embryo, arising from hemogenic endothelium in the ventral wall of the dorsal aorta (DA). cell (EC) polarity and vascular remodelling. Following this addition, at approximately HH stage 22 in chick embryos, for example, the SHF can be identified architecturally by an overlapping seam at the arteri... Development and maturation of the nascent cardiovascular system requires the recruitment of mural cells (MCs) around the vascular tree in a process called vascular myogenesis. The toponym Altilia lacks historical evidence, and most scholars - such as Ottavio Serena - tend to reject it. Only verified researchers can join ResearchGate and send messages to other members. Feline Leukemia Virus subgroup C Receptor 1 (Flvcr1) encodes two heme exporters: Flvcr1a, that localizes to the plasma membrane, and Flvcr1b, that localizes to mitochondria. The analysis of lipid molecules in living organism is an important step in deciphering metabolic pathways. © 2008-2021 ResearchGate GmbH. Here we show that the long bone vasculature generates a peculiar flow pattern, which is important for proper angiogenesis. Whereas such oxidative stress conditions would be harmful to normal cells, they facilitate tumor growth in multiple ways by causing DNA damage and genomic instability, and ultimately, by reprogramming cancer cell metabolism. The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved! How specific microRNAs intersect with and modulate angiogenic signaling cascades is unknown. z Stack time-lapse movie of Tg(kdrl:GFP)s843 siblings between 48 and 60 hpf is shown. Axon navigation is accompanied by migration of the GnRH+ neurons, which enter the anterior forebrain and home in the septo-hypothalamic area. This process can be interrupted... Metabolism has a decisive role in many fundamental biological processes, including organism development and tissue homeostasis. See the complete profile on LinkedIn and discover Massimo’s connections and jobs at similar companies.